Insulin resistance predicts sustained virological response to treatment of chronic hepatitis C independently of the IL28b rs12979860 polymorphism
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus reinfection among prisoners with sustained virological response after treatment for chronic hepatitis C.
BACKGROUND & AIMS We estimated HCV reinfection rate and its associated risk factors in inmates with chronic hepatitis C who had achieved sustained virological response (SVR) after completing combination therapy while in prison. METHODS Individuals who had achieved an SVR after treatment provided from January 2003 to December 2009 at four prisons in Catalonia, had been tested annually for HCV ...
متن کاملrole of il28-b polymorphism (rs12979860) on sustained virological response to pegylated interferon/ribavirin in iranian patients with chronic hepatitis c
results the analysis of data for c/t snp showed that the cc genotype is more common in the control group than in the group of patients. in contrast, the frequency of tt as a mutant genotype is more frequent in patients than in uninfected people. in addition, results showed a statistically significant relationship between cc, ct, and tt genotypes in sensitive and resistant groups (p value: < 0.0...
متن کاملMeta-analysis: impact of sustained virological response on insulin resistance during hepatitis C therapy
Aim: Previous studies have shown that sustained virological response to standard chronic hepatitis C therapy appears to be associated with insulin resistance, however, the discrete relationship remains controversial. This meta-analysis was designed to evaluate whether the achievement of sustained virological response interfered with insulin resistance in chronic hepatitis C patients undergoing ...
متن کاملHemochromatosis Gene Polymorphism as a Predictor of Sustained Virological Response to Antiviral Treatment in Egyptian Chronic Hepatitis C Patients
Aim The aim of this article is to assess HFE C282Y gene mutations as a predictor of sustained virological response (SVR) to anti-hepatitis C virus (HCV) treatment in Egyptian patients. Materials and methods One hundred and forty chronic hepatitis C (CHC) patients were divided into two groups: 70 patients achieved SVR and 70 patients were nonresponders (NRs). All patients were subjected to qua...
متن کاملHepatitis C reinfection after sustained virological response.
BACKGROUND & AIMS On-going risk behaviour can lead to hepatitis C virus (HCV) reinfection following successful treatment. We aimed to assess the incidence of persistent HCV reinfection in a population of people who inject drugs (PWID) who had achieved sustained virological response (SVR) seven years earlier. METHODS In 2004-2006 we conducted a multicentre treatment trial comprising HCV genoty...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2012
ISSN: 0269-2813
DOI: 10.1111/apt.12113